VINZENZ GRUPPE
     
 

Predictive Antibiotic Susceptibility Testing by Next-Generation Sequencing for Periprosthetic Joint Infections: Potential and Limitations

Lüftinger, Lukas, Ferreira, Ines, Frank, Bernhard J.H., Beisken, Stephan, Weinberger, Johannes, Von Haeseler, Arndt, Rattei, Thomas, Hofstaetter, Jochen, Posch, Andreas E. and Materna, Arne (2021) Predictive Antibiotic Susceptibility Testing by Next-Generation Sequencing for Periprosthetic Joint Infections: Potential and Limitations. Biomedicines.

[thumbnail of Predictive Antibiotic Susceptibility Testing by Next-Generation - Lüftinger et al..pdf]
Preview
Text
Predictive Antibiotic Susceptibility Testing by Next-Generation - Lüftinger et al..pdf - Published Version

Download (733kB) | Preview

Abstract

Joint replacement surgeries are one of the most frequent medical interventions globally. Infections of prosthetic joints are a major health challenge and typically require prolonged or even indefinite antibiotic treatment. As multidrug-resistant pathogens continue to rise globally, novel diagnostics are critical to ensure appropriate treatment and help with prosthetic joint infections (PJI) management. To this end, recent studies have shown the potential of molecular methods such as next-generation sequencing to complement established phenotypic, culture-based methods. Together with advanced bioinformatics approaches, next-generation sequencing can provide comprehensive information on pathogen identity as well as antimicrobial susceptibility, potentially enabling rapid diagnosis and targeted therapy of PJIs. In this review, we summarize current developments in next generation sequencing based predictive antibiotic susceptibility testing and discuss potential and limitations for common PJI pathogens.
Item Type: Fachpublikation (peer reviewed)
Divisions: Orthopädisches Spital Speising > Michael-Ogon-Labor
Depositing User: Research Lab
Date Deposited: 27 Sep 2021 07:44
Last Modified: 27 Sep 2021 07:44
URI: https://eprints.vinzenzgruppe.at/id/eprint/9250

Actions (login required)

View Item
View Item