A framework based on subject‑specific musculoskeletal models and Monte Carlo simulations to personalize muscle coordination retrainingTools Kainz, H, Koller, Willi, Wallnöfer, Elias, Bader, Till, Mindler, G.T. und Kranzl, A (2024) A framework based on subject‑specific musculoskeletal models and Monte Carlo simulations to personalize muscle coordination retraining. scientific report. Vorschau Kainz et al_2024_A framework based on subject-specific musculoskeletal models and Monte Carlo.pdf - Accepted Version Download (6MB) | Vorschau
Offizielle URL: https://doi.org/10.1038/s41598-024-53857-9
KurzfassungExcessive loads at lower limb joints can lead to pain and degenerative diseases. Altering joint loads
with muscle coordination retraining might help to treat or prevent clinical symptoms in a non-invasive
way. Knowing how much muscle coordination retraining can reduce joint loads and which muscles
have the biggest impact on joint loads is crucial for personalized gait retraining. We introduced a
simulation framework to quantify the potential of muscle coordination retraining to reduce joint
loads for an individuum. Furthermore, the proposed framework enables to pinpoint muscles, which
alterations have the highest likelihood to reduce joint loads. Simulations were performed based on
three-dimensional motion capture data of five healthy adolescents (femoral torsion 10°–29°, tibial
torsion 19°–38°) and five patients with idiopathic torsional deformities at the femur and/or tibia
(femoral torsion 18°–52°, tibial torsion 3°–50°). For each participant, a musculoskeletal model was
modified to match the femoral and tibial geometry obtained from magnetic resonance images. Each
participant’s model and the corresponding motion capture data were used as input for a Monte Carlo
analysis to investigate how different muscle coordination strategies influence joint loads. OpenSim
was used to run 10,000 simulations for each participant. Root-mean-square of muscle forces and
peak joint contact forces were compared between simulations. Depending on the participant,
altering muscle coordination led to a maximum reduction in hip, knee, patellofemoral and ankle
joint loads between 5 and 18%, 4% and 45%, 16% and 36%, and 2% and 6%, respectively. In some
but not all participants reducing joint loads at one joint increased joint loads at other joints. The
required alteration in muscle forces to achieve a reduction in joint loads showed a large variability
between participants. The potential of muscle coordination retraining to reduce joint loads depends
on the person’s musculoskeletal geometry and gait pattern and therefore showed a large variability
between participants, which highlights the usefulness and importance of the proposed framework to
personalize gait retraining.
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