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No Role of Osteocytic Osteolysis in the Development and Recovery of the Bone Phenotype Induced by Severe Secondary Hyperparathyroidism in Vitamin D Receptor Deficient Mice

Misof, Barbara M., Blouin, Stephane, Hofstaetter, Jochen, Roschger, Paul, Zwerina, Jochen and Erben, Reinhold G. (2020) No Role of Osteocytic Osteolysis in the Development and Recovery of the Bone Phenotype Induced by Severe Secondary Hyperparathyroidism in Vitamin D Receptor Deficient Mice. International Journal of Molecular Sciences.

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Abstract

Osteocytic osteolysis/perilacunar remodeling is thought to contribute to the maintenance of mineral homeostasis. Here, we utilized a reversible, adult-onset model of secondary hyperparathyroidism to study femoral bone mineralization density distribution (BMDD) and osteocyte lacunae sections (OLS) based on quantitative backscattered electron imaging. Male mice with a non-functioning vitamin D receptor (VDRD/D) or wild-type mice were exposed to a rescue diet (RD) (baseline) and subsequently to a low calcium challenge diet (CD). Thereafter, VDRD/D mice received either the CD, a normal diet (ND), or the RD. At baseline, BMDD and OLS characteristics were similar in VDRD/D and wild-type mice. The CD induced large cortical pores, osteomalacia, and a reduced epiphyseal average degree of mineralization in the VDRD/D mice relative to the baseline (
Item Type: Fachpublikation (peer reviewed)
Divisions: Orthopädisches Spital Speising > Michael-Ogon-Labor
Depositing User: Research Lab
Date Deposited: 27 Sep 2021 07:44
Last Modified: 27 Sep 2021 07:44
URI: https://eprints.vinzenzgruppe.at/id/eprint/9252

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