HFE hemochromatosis screening in patients with severe hip osteoarthritis: A prospective cross-sectional study

Despite the high frequency of HFE gene mutations in Western Europe, widespread screening of HFE hemochromatosis is not recommended due to its variable phenotype. Joint pain and a premature osteoarthritis-like disease including the hip joint are the most frequent manifestation in patients with HFE hemochromatosis and iron overload. Therefore, screening of patients with severe osteoarthritis of the hip could identify patients with HFE hemochromatosis.