VINZENZ GRUPPE
     
 

Clinically high-risk breast cancer displays markedly discordant molecular risk predictions between the MammaPrint and EndoPredict tests.

Jahn, Stephan Wenzel, Bösl, Andreas, Tsybrovskyy, Oleksiy, Gruber-Rossipal, Christine, Helfgott, Ruth, Fitzal, Florian, Knauer, Michael, Balic, Marija, Jasarevic, Zerina, Offner, Felix und Moinfar, Farid (2020) Clinically high-risk breast cancer displays markedly discordant molecular risk predictions between the MammaPrint and EndoPredict tests. British journal of cancer, 122 (12). pp. 1744-1746. ISSN 1532-1827

Für diesen Eintrag wurde kein Volltext-Dokument angefügt.

Kurzfassung

Inter-test concordance between the MammaPrint and the EndoPredict tests used to predict the risk of recurrence in breast cancer was evaluated in 94 oestrogen receptor-positive, HER2-negative breast cancers. We correlated histopathological data with clinical risk estimation as defined in the MINDACT trial. 42.6% (40/94) of cases were high-risk by MammaPrint, 44.7% (42/94) by EndoPredict (EPclin), and 45.7% (43/94) by clinical risk definition. Thirty-six percent of genomic risk predictions were discordant with a low inter-test correlation between EndoPredict and MammaPrint (p = 0.012; κ = 0.27, 95% CI [0.069, 0.46]). Clinical risk stratification did not correlate with MammaPrint (p = 0.476) but highly correlated with EndoPredict (p < 0.001). Consequently, clinically high-risk tumours (n = 43) were more frequently high-risk by EndoPredict than by MammaPrint (76.6% vs. 46.5%, p = 0.004), with 44% of cases discordantly classified and no significant association between genomic risk predictions (p = 0.294). Clinicians need to be aware that clinical pre-stratification can profoundly influence multigenomic test performance.

Typ des Eintrags: Fachpublikation (peer reviewed)
Bereiche: Ordensklinikum Linz Barmherzige Schwestern > Allgemeinchirurgie mit Viszeralchirurgie
Benutzer: Prof. Reinhold Fuegger
Hinterlegungsdatum: 03 Feb 2021 09:03
Letzte Änderung: 03 Feb 2021 09:03
URI: http://eprints.vinzenzgruppe.at/id/eprint/9099

Actions (login required)

Eintrag anzeigen Eintrag anzeigen