VINZENZ GRUPPE
     
 

The influence of breast cancer subtypes on axillary ultrasound accuracy: A retrospective single center analysis of 583 women.

Helfgott, Ruth, Mittlböck, Martina, Miesbauer, Maria, Moinfar, Farid, Haim, Silke, Mascherbauer, Maria, Schlagnitweit, Paul, Heck, Dietmar, Knauer, Michael und Fitzal, Florian (2019) The influence of breast cancer subtypes on axillary ultrasound accuracy: A retrospective single center analysis of 583 women. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 45 (4). pp. 538-543. ISSN 1532-2157

Für diesen Eintrag wurde kein Volltext-Dokument angefügt.

Kurzfassung

INTRODUCTION Axillary ultrasound staging (AUS) is an important tool to guide clinical decisions in breast cancer therapy, especially regarding axillary surgery but also radiation therapy. It is unknown whether biological subtypes influence axillary staging using ultrasound (AUS). METHOD This is a retrospective single center analysis. All patients with breast cancer, a preoperative axillary ultrasound and a complete surgical axillary staging were included between 1999 and 2014, except patients with neoadjuvant chemotherapy (NACT). The results of the AUS were compared with final pathological results. Biological subtypes were identified by immunohistochemistry. RESULTS 583 women were included in the study. Sensitivity, Specificity, positive and negative predictive value for AUS were 39%, 96%, 91% and 83%. While sensitivity was significantly lower in Luminal A and B patients (25.0%; 39.8%) as compared to non Luminal breast cancer patients (TN 68.8%; Her2+ 71.4%; p = 0.0032), there were no significant differences between the groups with respect to specificity, PPV and NPV. CONCLUSION Solely regarding sensitivity of AUS, our study could show significant differences between biological subtypes of breast cancer with lower sensitivity in Luminal patients. While PPV was excellent, standing for a low overtreatment rate using AUS for clinical decision making, sensitivity was poor overall, comparable to the results of other studies.

Typ des Eintrags: Fachpublikation (peer reviewed)
Bereiche: Ordensklinikum Linz Barmherzige Schwestern > Allgemeinchirurgie mit Viszeralchirurgie
Benutzer: Prof. Reinhold Fuegger
Hinterlegungsdatum: 17 Apr 2019 06:58
Letzte Änderung: 17 Apr 2019 06:58
URI: http://eprints.vinzenzgruppe.at/id/eprint/8706

Actions (login required)

Eintrag anzeigen Eintrag anzeigen