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. 2025 Oct;33(10):3665-3667.
doi: 10.1002/ksa.12716. Epub 2025 Jun 8.

Beyond the curve: The influence of cut-off selection methods on synovial biomarker interpretation for periprosthetic joint infection

Sujeesh Sebastian  1 , Jochen G Hofstaetter  1   2
Affiliations

Beyond the curve: The influence of cut-off selection methods on synovial biomarker interpretation for periprosthetic joint infection

Sujeesh Sebastian et al. Knee Surg Sports Traumatol Arthrosc. 2025 Oct.
No abstract available

Keywords: Youden's index; biomarkers; optimal threshold; receiver operating characteristic curve.

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References

REFERENCES

    1. Habibzadeh F, Habibzadeh P, Yadollahie M. On determining the most appropriate test cut‐off value: the case of tests with continuous results. Biochem Med. 2016;26(3):297–307.
    1. Hassanzad M, Hajian‐Tilaki K. Methods of determining optimal cut‐point of diagnostic biomarkers with application of clinical data in ROC analysis: an update review. BMC Med Res Methodol [Internet]. 2024;24(1):1–13.
    1. Leopold SS, Porcher R. Editorial: threshold p values in orthopaedic research—we know the problem. What is the solution? Clin Orthop Rel Res. 2018;476(9):1689–1691.
    1. Sebastian S, Mitterer JA, Ahmed Y, Frank BJH, Simon S, Hofstaetter JG. Synovial absolute polymorphonuclear neutrophil cell count: a simple and inexpensive marker for diagnosing periprosthetic hip and knee joint infections. Knee Surg Sports Traumatol Arthrosc. 2025;33(8):2905–2916.

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