Fastner, Gerd, Sedlmayer, Felix, Widder, Joachim, Metz, Martina, Geinitz, Hans, Kapp, Karin, Fesl, Christian, Sölkner, Lidija, Greil, Richard, Jakesz, Raimund, Kwasny, Werner, Heck, Dietmar, Bjelic-Radisic, Vesna, Balic, Marija, Stöger, Herbert, Wieder, Ursula, Zwrtek, Ronald, Semmler, Dagmar, Horvath, Wilfried, Melbinger-Zeinitzer, Elisabeth, Wiesholzer, Martin, Wette, Viktor und Gnant, Michael
(2020)
Endocrine therapy with or without whole breast irradiation in low-risk breast cancer patients after breast-conserving surgery: 10-year results of the Austrian Breast and Colorectal Cancer Study Group 8A trial.
European journal of cancer (Oxford, England : 1990), 127.
pp. 12-20.
ISSN 1879-0852
Für diesen Eintrag wurde kein Volltext-Dokument angefügt.
Kurzfassung
PURPOSE
To investigate long-term results of patients with hormonal receptor-positive breast cancer treated with breast-conserving surgery (BCS) and consecutive endocrine therapy (ET) with or without whole breast irradiation (WBI).
METHODS AND MATERIALS
Within the 8 A trial of the Austrian Breast and Colorectal Cancer Study Group, a total of 869 patients received ET after BCS which was randomly followed by WBI (n = 439, group 1) or observation (n = 430, group 2). WBI was applied up to a mean total dosage of 50 Gy (+/- 10 Gy boost) in conventional fractionation.
RESULTS
After a median follow-up of 9.89 years, 10 in-breast recurrences (IBRs) were observed in group 1 and 31 in group 2, resulting in a 10-year local recurrence-free survival (LRFS) of 97.5% and 92.4%, respectively (p = 0.004). This translated into significantly higher rates for disease-free survival (DFS): 94.5% group 1 vs 88.4% group 2, p = 0.0156. For distant metastases-free survival (DMFS) and overall survival (OS), respective 10-year rates amounted 96.7% and 86.6% for group 1 versus 96.4% and 87.6%, for group 2 (ns). WBI (hazard ratio [HR]: 0.27, p < 0.01) and tumour grading (HR: 3.76, p = 0.03) were found as significant predictors for IBR in multiple cox regression analysis.
CONCLUSIONS
After a median follow-up of 10 years, WBI resulted in a better local control and DFS compared with ET alone. The omission of WBI and tumour grading, respectively, were the only negative predictors for LRFS.
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