VINZENZ GRUPPE
     
 

Endocrine therapy with or without whole breast irradiation in low-risk breast cancer patients after breast-conserving surgery: 10-year results of the Austrian Breast and Colorectal Cancer Study Group 8A trial.

Fastner, Gerd, Sedlmayer, Felix, Widder, Joachim, Metz, Martina, Geinitz, Hans, Kapp, Karin, Fesl, Christian, Sölkner, Lidija, Greil, Richard, Jakesz, Raimund, Kwasny, Werner, Heck, Dietmar, Bjelic-Radisic, Vesna, Balic, Marija, Stöger, Herbert, Wieder, Ursula, Zwrtek, Ronald, Semmler, Dagmar, Horvath, Wilfried, Melbinger-Zeinitzer, Elisabeth, Wiesholzer, Martin, Wette, Viktor und Gnant, Michael (2020) Endocrine therapy with or without whole breast irradiation in low-risk breast cancer patients after breast-conserving surgery: 10-year results of the Austrian Breast and Colorectal Cancer Study Group 8A trial. European journal of cancer (Oxford, England : 1990), 127. pp. 12-20. ISSN 1879-0852

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Kurzfassung

PURPOSE To investigate long-term results of patients with hormonal receptor-positive breast cancer treated with breast-conserving surgery (BCS) and consecutive endocrine therapy (ET) with or without whole breast irradiation (WBI). METHODS AND MATERIALS Within the 8 A trial of the Austrian Breast and Colorectal Cancer Study Group, a total of 869 patients received ET after BCS which was randomly followed by WBI (n = 439, group 1) or observation (n = 430, group 2). WBI was applied up to a mean total dosage of 50 Gy (+/- 10 Gy boost) in conventional fractionation. RESULTS After a median follow-up of 9.89 years, 10 in-breast recurrences (IBRs) were observed in group 1 and 31 in group 2, resulting in a 10-year local recurrence-free survival (LRFS) of 97.5% and 92.4%, respectively (p = 0.004). This translated into significantly higher rates for disease-free survival (DFS): 94.5% group 1 vs 88.4% group 2, p = 0.0156. For distant metastases-free survival (DMFS) and overall survival (OS), respective 10-year rates amounted 96.7% and 86.6% for group 1 versus 96.4% and 87.6%, for group 2 (ns). WBI (hazard ratio [HR]: 0.27, p < 0.01) and tumour grading (HR: 3.76, p = 0.03) were found as significant predictors for IBR in multiple cox regression analysis. CONCLUSIONS After a median follow-up of 10 years, WBI resulted in a better local control and DFS compared with ET alone. The omission of WBI and tumour grading, respectively, were the only negative predictors for LRFS.

Typ des Eintrags: Artikel
Bereiche: Ordensklinikum Linz Barmherzige Schwestern > Radio-Onkologie und Strahlentherapie
Benutzer: Prof. Dr. Hans Geinitz
Hinterlegungsdatum: 07 Apr 2020 11:30
Letzte Änderung: 07 Apr 2020 11:30
URI: http://eprints.vinzenzgruppe.at/id/eprint/8994

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