VINZENZ GRUPPE
     
 

Signal-averaged electrocardiography in patients with AL (primary) amyloidosis.

Dubrey, S W, Bilazarian, S, LaValley, M, Reisinger, J, Skinner, M und Falk, R H (1997) Signal-averaged electrocardiography in patients with AL (primary) amyloidosis. American heart journal, 134 (6). pp. 994-1001. ISSN 0002-8703

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Kurzfassung

One hundred thirty-three patients with biopsy-proven AL amyloidosis were studied with echocardiography, Holter recording, 12-lead electrocardiography, and signal-averaged electrocardiograms. Features from these tests were analyzed in relation to their effect on mortality. Late potentials were more frequent in patients with echocardiographic evidence of cardiac amyloidosis (31%) compared with patients with normal echocardiograms (9%, p < 0.003). One hundred six of the 133 patients died during follow-up, of which 34 were nonsudden cardiac deaths and 33 were sudden deaths. Abnormal echocardiograms and signal-averaged electrocardiograms were each predictive of all-cause cardiac death (p < 0.0001 ) and sudden cardiac death (p < 0.0001). Abnormal signal-averaged electrocardiograms were also independently predictive of sudden death in the subgroup of patients with an abnormal echocardiogram (p < 0.05). Thus late potentials are predictive of sudden death in patients with AL amyloidosis and provide independent prognostic information in patients with echocardiographic evidence of amyloid involvement.

Typ des Eintrags: Artikel
Themengebiete: WG Kardiovaskuläres System
Benutzer: Dr. Christian Vogel
Hinterlegungsdatum: 15 Nov 2012 09:10
Letzte Änderung: 15 Nov 2012 09:10
URI: http://eprints.vinzenzgruppe.at/id/eprint/13

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